Cell：华人团队开发新型计算框架——「蒲公英」，发现哮喘核心致病基因，带来治疗新靶点
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Merged summary
TL;DR — DANDELION is a computational framework that combines trans-regulatory effects with exome burden data to identify disease-driving genes. In asthma, it uncovered SLC27A3, SCD, and protein palmitoylation as potential therapeutic targets.
- Prioritizes disease-proximal mediator genes influenced by distal disease-associated genes.
- Identifies candidates missed by GWAS and methods such as PoPS.
- CRISPR screens confirmed that most prioritized genes affect asthma-relevant epithelial and T-cell phenotypes.
- Mouse studies linked SLC27A3 and SCD to airway inflammation and remodeling.
Note: The FMT summary concerns an unrelated depression trial and was excluded rather than merged.
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Cell：华人团队开发新型计算框架——「蒲公英」，发现哮喘核心致病基因，带来治疗新靶点
TL;DR - A Cell study introduces DANDELION, a computational framework that integrates trans-regulatory effects with exome burden data to prioritize disease-driving genes. Applied to asthma, it identified SLC27A3 and SCD and implicated protein palmitoylation in lung inflammation.
- DANDELION targets disease-proximal genes that mediate effects from more distal disease-associated genes.
- It identified candidates missed by GWAS and polygenic priority scoring methods such as PoPS.
- CRISPR screens showed that most prioritized genes regulate asthma-relevant epithelial and T-cell phenotypes.
- Mouse studies linked SLC27A3 and SCD to airway inflammation and remodeling, suggesting new therapeutic targets.
Cell子刊封面：王刚/杨健/周晶晶合作揭示，粪菌移植可改善抑郁症
TL;DR - A randomized, double-blind trial found that adjunctive fecal microbiota transplantation (FMT) may accelerate escitalopram’s antidepressant effects in major depressive disorder, potentially through gut microbiome, bile acid, and inflammatory pathways.
- Remission rates at week 8 did not differ significantly between FMT and placebo groups.
- FMT produced larger reductions in HAMD-17 depression scores at weeks 2 and 8.
- Donor microbes engrafted long-term, enriching beneficial Lachnospiraceae and Oscillospiraceae bacteria.
- Increased bile acids and reduced systemic inflammation were associated with symptom improvement, while FMT safety was comparable to placebo.