Glucose-responsive probiotics for glycaemic modulation in mice and monkeys

TL;DR - Engineered probiotics use a synthetic glucose-responsive circuit to detect elevated glucose and release therapeutic factors in the gut. The approach enabled oral, transient, sense-and-respond diabetes control in mouse and primate models.

• Probiotics transiently colonize the gut rather than persisting indefinitely.
• The synthetic circuit activates therapeutic secretion when glucose rises.
• The system demonstrated glycaemic modulation in both mice and monkeys.
• Results support a potentially safer, responsive oral strategy for diabetes treatment.