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Glucose-responsive probiotics for glycaemic modulation in mice and monkeys

Research Medical/Healthcare AI

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TL;DR - Engineered probiotics use a synthetic glucose-responsive circuit to detect elevated glucose and release therapeutic factors in the gut. The approach enabled oral, transient, sense-and-respond diabetes control in mouse and primate models.

  • Probiotics transiently colonize the gut rather than persisting indefinitely.
  • The synthetic circuit activates therapeutic secretion when glucose rises.
  • The system demonstrated glycaemic modulation in both mice and monkeys.
  • Results support a potentially safer, responsive oral strategy for diabetes treatment.

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Glucose-responsive probiotics for glycaemic modulation in mice and monkeys

Nature Ningzi Guan, Deqiang Kong, Xianyun Gao, Lingxue Niu, Yang Zhou, Guiling Yu, Tian Gao, Mengyao Liu, Wenbo Ma, Yiyu Jin, Jianli Yin, Shangang Zhao, Haifeng Ye 2026-08-12 doi:10.1038/s41586-026-10909-6
Public signals OpenAlex citations 0
Providers: Hugging Face · N/A OpenAlex · Citations 0 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-12 14:28:07.066901 UTC

TL;DR - Engineered probiotics use a synthetic glucose-responsive circuit to detect elevated glucose and release therapeutic factors in the gut. The approach enabled oral, transient, sense-and-respond diabetes control in mouse and primate models.

  • Probiotics transiently colonize the gut rather than persisting indefinitely.
  • The synthetic circuit activates therapeutic secretion when glucose rises.
  • The system demonstrated glycaemic modulation in both mice and monkeys.
  • Results support a potentially safer, responsive oral strategy for diabetes treatment.
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