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Luminescent-reaction-enabled super-resolution imaging

Nature Biomedical Imaging Wenxin Zhu, Chi Zhang, Jiahui Gui, Yibo Yang, Yuxin Wan, Xin Wang, Liying Qu, Ao Guo, Ziqing Zhang, Zhenqian Han, Weisong Zhao, Jiandong Feng 2026-08-12

TL;DR - A chemistry-based super-resolution framework enables 3D, laser-free imaging of live cells with high sensitivity and ultralong observation times. It addresses spatiotemporal-resolution limitations of prior reaction-based imaging methods.

  • Uses luminescent reactions rather than laser excitation.
  • Supports three-dimensional super-resolution imaging in living cells.
  • Combines high sensitivity with extended imaging duration.
  • Improves the spatiotemporal capabilities of reaction-based imaging.

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