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Luminescent-reaction-enabled super-resolution imaging

Research Biomedical Imaging

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TL;DR - A chemistry-based super-resolution framework enables 3D, laser-free imaging of live cells with high sensitivity and ultralong observation times. It addresses spatiotemporal-resolution limitations of prior reaction-based imaging methods.

  • Uses luminescent reactions rather than laser excitation.
  • Supports three-dimensional super-resolution imaging in living cells.
  • Combines high sensitivity with extended imaging duration.
  • Improves the spatiotemporal capabilities of reaction-based imaging.

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Luminescent-reaction-enabled super-resolution imaging

Nature Wenxin Zhu, Chi Zhang, Jiahui Gui, Yibo Yang, Yuxin Wan, Xin Wang, Liying Qu, Ao Guo, Ziqing Zhang, Zhenqian Han, Weisong Zhao, Jiandong Feng 2026-08-12 doi:10.1038/s41586-026-10889-7
Public signals OpenAlex citations 0 · Semantic Scholar citations 0 · Semantic Scholar influential citations 0
Providers: Hugging Face · N/A OpenAlex · Citations 0 Publisher · N/A Semantic Scholar · Citations 0 · Influential citations 0 X · N/A Fetched 2026-09-12 14:28:02.201454 UTC

TL;DR - A chemistry-based super-resolution framework enables 3D, laser-free imaging of live cells with high sensitivity and ultralong observation times. It addresses spatiotemporal-resolution limitations of prior reaction-based imaging methods.

  • Uses luminescent reactions rather than laser excitation.
  • Supports three-dimensional super-resolution imaging in living cells.
  • Combines high sensitivity with extended imaging duration.
  • Improves the spatiotemporal capabilities of reaction-based imaging.
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