‹ back to 2026-08-13

In vivo genome-wide CRISPR screens of human T cells in solid tumours

Nature Medical/Healthcare AI Qi Liu, Peixin Amy Chen, Esha Urs, Shimin Zhang, Maya M. Arce, Charlotte H. Wang, Jun Yan, Vinh Q. Nguyen, Zhongmei Li, Jin Seo, Nupura Kale, Fanglue Peng, Yikai Luo, Laine Goudy, Taylor N. LaFlam, Haixia Zhong, Chandrima Modak, Emma Dann, Jae Hyung Jung, Amanda Kirane, Allison Betof Warner, Boi Bryant Quach, Zinaida Good, Brian R. Shy, Eric Shifrut, Sagar P. Bapat, Greg M. Allen, Justin Eyquem, Katherine Fuh, Stacie E. Dodgson, Jason G. Cyster, Alexander Marson, Julia Carnevale 2026-08-12

TL;DR - This Nature study presents an in vivo genome-wide CRISPR screening model that recovers human T cells from solid tumours. It could reveal targets for improving CAR T-cell antitumour activity.

Screens human T cells genome-wide within solid-tumour environments.
Enables recovery of tumour-infiltrating human T cells for analysis.
Seeks actionable genetic targets to enhance CAR T-cell therapies.
Specific targets and performance results are not provided in the excerpt.

view merged work →