In vivo genome-wide CRISPR screens of human T cells in solid tumours
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TL;DR - This Nature study presents an in vivo genome-wide CRISPR screening model that recovers human T cells from solid tumours. It could reveal targets for improving CAR T-cell antitumour activity.
- Screens human T cells genome-wide within solid-tumour environments.
- Enables recovery of tumour-infiltrating human T cells for analysis.
- Seeks actionable genetic targets to enhance CAR T-cell therapies.
- Specific targets and performance results are not provided in the excerpt.
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In vivo genome-wide CRISPR screens of human T cells in solid tumours
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TL;DR - This Nature study presents an in vivo genome-wide CRISPR screening model that recovers human T cells from solid tumours. It could reveal targets for improving CAR T-cell antitumour activity.
- Screens human T cells genome-wide within solid-tumour environments.
- Enables recovery of tumour-infiltrating human T cells for analysis.
- Seeks actionable genetic targets to enhance CAR T-cell therapies.
- Specific targets and performance results are not provided in the excerpt.