Rb-driven transcription limits its tumour-suppressive effects in breast cancer

TL;DR - This Nature study reports that CDK4/6 inhibition redirects retinoblastoma protein (Rb) chromatin binding toward oestrogen-responsive genes in breast cancer, weakening sustained therapeutic cell-cycle arrest.

• Rb-driven transcription can limit Rb’s tumour-suppressive effects.
• CDK4/6 inhibition changes Rb chromatin occupancy rather than acting solely through cell-cycle suppression.
• Activation of oestrogen-responsive genes counteracts maintenance of treatment-induced arrest.
• The findings identify a potential mechanism of reduced CDK4/6 inhibitor efficacy.