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Rb-driven transcription limits its tumour-suppressive effects in breast cancer

Research Cancer Biology

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TL;DR - This Nature study reports that CDK4/6 inhibition redirects retinoblastoma protein (Rb) chromatin binding toward oestrogen-responsive genes in breast cancer, weakening sustained therapeutic cell-cycle arrest.

  • Rb-driven transcription can limit Rb’s tumour-suppressive effects.
  • CDK4/6 inhibition changes Rb chromatin occupancy rather than acting solely through cell-cycle suppression.
  • Activation of oestrogen-responsive genes counteracts maintenance of treatment-induced arrest.
  • The findings identify a potential mechanism of reduced CDK4/6 inhibitor efficacy.

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Rb-driven transcription limits its tumour-suppressive effects in breast cancer

Nature April C. Watt, Antonio Ahn, Catherine Blyth, Julia R. Dixon-Douglas, Krutika Ambani, Rhiannon Coulson, Michael Taylor, Keefe T. Chan, Catherine Dietrich, Brendan E. Russ, Susanne Ramm, Christabella A. Mahendra, Kun-Hui Lu, Nichelle Pires, Jesus Garcia-Sannicolas, Olivia Voulgaris, Sheena Nunag, Ching-Seng Ang, Mark A. Dawson, Elgene Lim, Monica Arnedos, Sarat Chandarlapaty, Fabrice André, Shom Goel 2026-08-12 doi:10.1038/s41586-026-10886-w
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Providers: Hugging Face · N/A OpenAlex · Citations 1 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-12 14:27:53.354342 UTC

TL;DR - This Nature study reports that CDK4/6 inhibition redirects retinoblastoma protein (Rb) chromatin binding toward oestrogen-responsive genes in breast cancer, weakening sustained therapeutic cell-cycle arrest.

  • Rb-driven transcription can limit Rb’s tumour-suppressive effects.
  • CDK4/6 inhibition changes Rb chromatin occupancy rather than acting solely through cell-cycle suppression.
  • Activation of oestrogen-responsive genes counteracts maintenance of treatment-induced arrest.
  • The findings identify a potential mechanism of reduced CDK4/6 inhibitor efficacy.
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