Temporal uncoupling of radial glia lineage progression in cortical organoids

TL;DR - Lineage tracing reveals that radial glia in cortical organoids exhibit unusually plastic proliferation and reduced clonal neuronal diversity. This suggests missing non-cell-autonomous niche signals disrupt faithful timing of cortical development.

• Tracks radial glia progenitor lineages in stem-cell-derived cortical organoids.
• Finds temporal uncoupling and high plasticity in progenitor proliferation.
• Reports reduced neuronal diversity within individual clones.
• Identifies external niche cues as essential for controlling cortical lineage progression.