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Temporal uncoupling of radial glia lineage progression in cortical organoids

Research Brain Organoids

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TL;DR - Lineage tracing reveals that radial glia in cortical organoids exhibit unusually plastic proliferation and reduced clonal neuronal diversity. This suggests missing non-cell-autonomous niche signals disrupt faithful timing of cortical development.

  • Tracks radial glia progenitor lineages in stem-cell-derived cortical organoids.
  • Finds temporal uncoupling and high plasticity in progenitor proliferation.
  • Reports reduced neuronal diversity within individual clones.
  • Identifies external niche cues as essential for controlling cortical lineage progression.

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Temporal uncoupling of radial glia lineage progression in cortical organoids

Nature Melissa Stouffer, Osvaldo A. Miranda, Florian M. Pauler, Fabrizia Pipicelli, Carmen Streicher, Giselle Cheung, Simon Hippenmeyer 2026-08-12 doi:10.1038/s41586-026-10916-7
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Providers: Hugging Face · N/A OpenAlex · Citations 0 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-12 14:27:31.179965 UTC

TL;DR - Lineage tracing reveals that radial glia in cortical organoids exhibit unusually plastic proliferation and reduced clonal neuronal diversity. This suggests missing non-cell-autonomous niche signals disrupt faithful timing of cortical development.

  • Tracks radial glia progenitor lineages in stem-cell-derived cortical organoids.
  • Finds temporal uncoupling and high plasticity in progenitor proliferation.
  • Reports reduced neuronal diversity within individual clones.
  • Identifies external niche cues as essential for controlling cortical lineage progression.
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