Cell子刊封面：王刚/杨健/周晶晶合作揭示，粪菌移植可改善抑郁症

TL;DR - A randomized, double-blind trial found that adjunctive fecal microbiota transplantation (FMT) may accelerate escitalopram’s antidepressant effects in major depressive disorder, potentially through gut microbiome, bile acid, and inflammatory pathways.

• Remission rates at week 8 did not differ significantly between FMT and placebo groups.
• FMT produced larger reductions in HAMD-17 depression scores at weeks 2 and 8.
• Donor microbes engrafted long-term, enriching beneficial Lachnospiraceae and Oscillospiraceae bacteria.
• Increased bile acids and reduced systemic inflammation were associated with symptom improvement, while FMT safety was comparable to placebo.