3D epigenome of glial cell types in developing human cortex

TL;DR - This Nature study maps the 3D epigenomic organization of four glial cell types in the developing human cortex. It connects cell-type-specific gene regulation and chromatin interactions to neuropsychiatric disease variants and human cortical evolution.

• Profiles glial cells from the mid-gestation human cortex using integrative 3D epigenomic methods.
• Identifies regulatory elements and chromatin interactions specific to individual glial cell types.
• Provides a framework for interpreting the potential roles of non-coding neuropsychiatric disease variants.
• Highlights regulatory features relevant to human-specific cortical evolution.