3D epigenome of glial cell types in developing human cortex
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TL;DR - This Nature study maps the 3D epigenomic organization of four glial cell types in the developing human cortex. It connects cell-type-specific gene regulation and chromatin interactions to neuropsychiatric disease variants and human cortical evolution.
- Profiles glial cells from the mid-gestation human cortex using integrative 3D epigenomic methods.
- Identifies regulatory elements and chromatin interactions specific to individual glial cell types.
- Provides a framework for interpreting the potential roles of non-coding neuropsychiatric disease variants.
- Highlights regulatory features relevant to human-specific cortical evolution.
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3D epigenome of glial cell types in developing human cortex
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TL;DR - This Nature study maps the 3D epigenomic organization of four glial cell types in the developing human cortex. It connects cell-type-specific gene regulation and chromatin interactions to neuropsychiatric disease variants and human cortical evolution.
- Profiles glial cells from the mid-gestation human cortex using integrative 3D epigenomic methods.
- Identifies regulatory elements and chromatin interactions specific to individual glial cell types.
- Provides a framework for interpreting the potential roles of non-coding neuropsychiatric disease variants.
- Highlights regulatory features relevant to human-specific cortical evolution.