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TM184C is a GPCR-like regulator of intercellular exchange and autophagy

Nature Cell Biology Kyutae D. Lee, Samuel Taylor, Jennifer Arcuri, Shraddha Chandthakuri, Jacinda Pujols, Bruno Colon, Qiang Wang, Chenzhou Wu, Zhipeng Meng, Sebastian J. Thompson-Ceccato, Jonathan Mitchell, Defne Bayik, Alexandra Carbone, Vladlen Slepak, Tatiana I. Slepak, Scott M. Welford, Michael E. Ivan, Dazhi Wang, Blake O. Goldberg, Warner Baringer, Elvis Maradzike, Daniel G. Isom 2026-09-09

TL;DR - A Nature study identifies TM184C as an ancient GPCR-like “superdark” protein involved in regulating autophagy, intercellular connectivity, and material exchange. It highlights the biological discovery potential of investigating understudied proteins.

TM184C is characterized as a G-protein-coupled receptor-like regulator.
The protein is implicated in autophagy and exchange between cells.
Its study underscores the value of exploring the poorly characterized human proteome and related proteins beyond it.

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