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TM184C is a GPCR-like regulator of intercellular exchange and autophagy

Research Cell Biology

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TL;DR - A Nature study identifies TM184C as an ancient GPCR-like “superdark” protein involved in regulating autophagy, intercellular connectivity, and material exchange. It highlights the biological discovery potential of investigating understudied proteins.

  • TM184C is characterized as a G-protein-coupled receptor-like regulator.
  • The protein is implicated in autophagy and exchange between cells.
  • Its study underscores the value of exploring the poorly characterized human proteome and related proteins beyond it.

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TM184C is a GPCR-like regulator of intercellular exchange and autophagy

Nature Kyutae D. Lee, Samuel Taylor, Jennifer Arcuri, Shraddha Chandthakuri, Jacinda Pujols, Bruno Colon, Qiang Wang, Chenzhou Wu, Zhipeng Meng, Sebastian J. Thompson-Ceccato, Jonathan Mitchell, Defne Bayik, Alexandra Carbone, Vladlen Slepak, Tatiana I. Slepak, Scott M. Welford, Michael E. Ivan, Dazhi Wang, Blake O. Goldberg, Warner Baringer, Elvis Maradzike, Daniel G. Isom 2026-09-09 doi:10.1038/s41586-026-10993-8
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Providers: Hugging Face · N/A OpenAlex · Citations 1 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-25 14:21:16.954606 UTC

TL;DR - A Nature study identifies TM184C as an ancient GPCR-like “superdark” protein involved in regulating autophagy, intercellular connectivity, and material exchange. It highlights the biological discovery potential of investigating understudied proteins.

  • TM184C is characterized as a G-protein-coupled receptor-like regulator.
  • The protein is implicated in autophagy and exchange between cells.
  • Its study underscores the value of exploring the poorly characterized human proteome and related proteins beyond it.
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