An ultralow-background far-red light-responsive optogenetic tool based on an engineered biliverdin-binding domain

TL;DR - Researchers developed FenixS and Ash1, a compact engineered protein pair that heterodimerizes under far-red light with ultralow background activity, offering a new tool for optogenetic control.

• FenixS is based on an engineered biliverdin-binding domain.
• Far-red light triggers heterodimerization between FenixS and Ash1.
• The system is designed for low background activation when illumination is absent.
• The provided summary does not report quantitative performance or application results.