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An ultralow-background far-red light-responsive optogenetic tool based on an engineered biliverdin-binding domain

Research Optogenetic Tools

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TL;DR - Researchers developed FenixS and Ash1, a compact engineered protein pair that heterodimerizes under far-red light with ultralow background activity, offering a new tool for optogenetic control.

  • FenixS is based on an engineered biliverdin-binding domain.
  • Far-red light triggers heterodimerization between FenixS and Ash1.
  • The system is designed for low background activation when illumination is absent.
  • The provided summary does not report quantitative performance or application results.

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An ultralow-background far-red light-responsive optogenetic tool based on an engineered biliverdin-binding domain

Nature Methods Giang N. T. Le, Lam M. T. Pham, Boyan Xue, Maruti Uppalapati, G. Andrew Woolley 2026-09-11 doi:10.1038/s41592-026-03223-6
Public signals OpenAlex citations 0
Providers: Hugging Face · N/A OpenAlex · Citations 0 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-25 14:20:49.112880 UTC

TL;DR - Researchers developed FenixS and Ash1, a compact engineered protein pair that heterodimerizes under far-red light with ultralow background activity, offering a new tool for optogenetic control.

  • FenixS is based on an engineered biliverdin-binding domain.
  • Far-red light triggers heterodimerization between FenixS and Ash1.
  • The system is designed for low background activation when illumination is absent.
  • The provided summary does not report quantitative performance or application results.
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