Cohesin reshapes replication fork contacts to aid fork slowing and reversal

TL;DR - This Nature study finds that cohesin-mediated loop extrusion reorganizes replication-fork contacts under stress, slowing and reversing forks to help preserve genome stability.

• Cohesin limits coupling between sister replication forks.
• It tethers nearby forks when replication stress occurs.
• These contact changes promote fork reversal and reduce fork progression.
• The resulting response helps safeguard genome stability.