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Cohesin reshapes replication fork contacts to aid fork slowing and reversal

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TL;DR - This Nature study finds that cohesin-mediated loop extrusion reorganizes replication-fork contacts under stress, slowing and reversing forks to help preserve genome stability.

  • Cohesin limits coupling between sister replication forks.
  • It tethers nearby forks when replication stress occurs.
  • These contact changes promote fork reversal and reduce fork progression.
  • The resulting response helps safeguard genome stability.

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Cohesin reshapes replication fork contacts to aid fork slowing and reversal

Nature Daniel González-Acosta, Daniel Giménez-Llorente, Melani Rodrigues, Moses Aouami, Orhi Barroso-Gomila, Javier Muñoz, Ana Cuadrado, Ana Losada, Massimo Lopes 2026-09-16 doi:10.1038/s41586-026-11034-0
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Providers: Hugging Face · N/A OpenAlex · Citations 0 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-25 14:17:53.101029 UTC

TL;DR - This Nature study finds that cohesin-mediated loop extrusion reorganizes replication-fork contacts under stress, slowing and reversing forks to help preserve genome stability.

  • Cohesin limits coupling between sister replication forks.
  • It tethers nearby forks when replication stress occurs.
  • These contact changes promote fork reversal and reduce fork progression.
  • The resulting response helps safeguard genome stability.
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