Vast cellular gene-expression atlas could transform how scientists understand brain ageing and disease

TL;DR - A large single-nucleus RNA-sequencing atlas maps gene-expression changes in the human prefrontal cortex across ageing, health, and disease. It could help researchers identify cell-specific molecular patterns associated with brain ageing and disorders.

• Profiles gene expression at single-nucleus resolution, distinguishing changes among brain cell types.
• Spans the human lifespan and includes both healthy and disease contexts.
• Focuses on the prefrontal cortex, a region central to cognition and affected by ageing and neurological disease.
• The provided summary does not specify the atlas’s scale, disease cohorts, or individual molecular findings.