🛰️ Daily AI Frontier
‹ back to 2026-08-24

KREL: Automatic Medical Coding via Knowledge-Guided Reasoning over Clinical Evidence with LLMs

Research Medical/Healthcare AI

Ranking

Overall 75
Content 90
Popularity 39

Observed public metrics from 1 member.

Representative image for KREL: Automatic Medical Coding via Knowledge-Guided Reasoning over Clinical Evidence with LLMs

Merged summary

TL;DR - KREL is an LLM-based framework for automatically assigning ICD codes to clinical notes by combining clinical-evidence reasoning with structured coding guidelines. This knowledge-guided approach aims to reduce hallucinations, improve standards compliance, and handle challenges such as long notes and a large label space.

  • Integrates external ICD coding guidelines directly into the LLM reasoning process.
  • Couples clinical-text interpretation with evidence-based, multi-step code selection.
  • Addresses limitations of extreme multi-label classification and unconstrained generative approaches.
  • Consistently outperforms strong pretrained language model and state-of-the-art LLM baselines on benchmark datasets.

Sources (1)

KREL: Automatic Medical Coding via Knowledge-Guided Reasoning over Clinical Evidence with LLMs

arXiv cs.CL Xubin Chen, Yipeng Zhou, Wen Sun, Chengkai Huang, Xiaoming Fu, Quan Z. Sheng 2026-08-21 arXiv:2608.20887
Public signals Semantic Scholar citations 0 · Semantic Scholar influential citations 0
Providers: Hugging Face · N/A OpenAlex · N/A Publisher · N/A Semantic Scholar · Citations 0 · Influential citations 0 X · N/A Fetched 2026-09-17 14:29:31.335126 UTC

TL;DR - KREL is an LLM-based framework for automatically assigning ICD codes to clinical notes by combining clinical-evidence reasoning with structured coding guidelines. This knowledge-guided approach aims to reduce hallucinations, improve standards compliance, and handle challenges such as long notes and a large label space.

  • Integrates external ICD coding guidelines directly into the LLM reasoning process.
  • Couples clinical-text interpretation with evidence-based, multi-step code selection.
  • Addresses limitations of extreme multi-label classification and unconstrained generative approaches.
  • Consistently outperforms strong pretrained language model and state-of-the-art LLM baselines on benchmark datasets.
item →