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Developmental xenocortication using human-derived organoids in mice

Research Medical/Healthcare AI

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TL;DR - This Nature study develops “xenocortication,” using human-derived neural organoids to introduce human neurons into developing mouse cortical circuits. The approach enables circuit- and behaviour-level investigation of human neurodevelopment in vivo.

  • Human-derived organoids provide the neurons used for xenocortication in mice.
  • The model connects cellular neurodevelopment with circuit- and behavioural analysis.
  • The supplied abstract does not specify experimental outcomes, disease applications, or quantitative results.

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Developmental xenocortication using human-derived organoids in mice

Nature Konstantin Kaganovsky, Kevin W. Kelley, Tilo Gschwind, Paul M. Harary, John Kochalka, Alexander D. White, Garikoitz Lerma-Usabiaga, Xiaoyu Chen, Omer Revah, Felicity Gore, Ayano Aoyama, Jennifer L. Shadrach, Se-Jin Yoon, Alfredo Valencia, Satoe Ogawa, Noah Reis, Hannes Vogel, Brian Wandell, Julia A. Kaltschmidt, Ivan Soltesz, Karl Deisseroth, Sergiu P. Pașca 2026-09-16 doi:10.1038/s41586-026-11032-2
Public signals OpenAlex citations 2
Providers: Hugging Face · N/A OpenAlex · Citations 2 Publisher · N/A Semantic Scholar · N/A X · N/A Fetched 2026-09-25 14:18:53.835073 UTC

TL;DR - This Nature study develops “xenocortication,” using human-derived neural organoids to introduce human neurons into developing mouse cortical circuits. The approach enables circuit- and behaviour-level investigation of human neurodevelopment in vivo.

  • Human-derived organoids provide the neurons used for xenocortication in mice.
  • The model connects cellular neurodevelopment with circuit- and behavioural analysis.
  • The supplied abstract does not specify experimental outcomes, disease applications, or quantitative results.
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